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Studies show that nicotine withdrawal contributes greatly to the failure of tobacco cessation efforts. Nicotine stimulates almost every cell in the body by activating nicotine receptors. Once nicotine is removed, cells scream for stimulation, causing stress and possibly cessation failure. Put mildly, quitting can be terribly hard, especially for the first month. Unfortunately, triggers to use again can come on without warning for a year or more.